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The Rise of Microdosing Psilocybin

Updated: Feb 1

A psilocybin microdose refers to a sub-perceptual dose of these hallucinogenic mushrooms. This implies that if your dosage is accurately determined, microdosing psilocybin will not produce any noticeable hallucinogenic effects. This allows you to carry out your daily activities, such as work, socializing, and operating heavy machinery, as you normally would.


Your microdosing journey is unique to your individual physiology, meaning that the insights and benefits you experience will be specific to your brain chemistry and personal circumstances.

Microdosing psilocybin has been reported to improve focus and concentration, suggesting potential effectiveness in managing Attention Deficit Hyperactivity Disorder (ADHD). It has also been associated with enhancements in creativity, critical thinking skills, motivation, and mental resilience, particularly in stressful situations.

Anecdotal evidence supports the use of microdosing mushrooms for mental health improvement, with many reporting reduced anxiety levels and positive effects on people struggling with post-traumatic stress disorder, treatment-resistant depression, or major depressive disorder.


Studies, such as a 2018 study led by Calvin Ly and colleagues, have shown that serotonergic psychedelics like LSD and psilocybin mushrooms can increase neuritogenesis and spinogenesis, which is the development of dendritic spines and axon terminals in neurons.

In individuals with chronic stress or psychological and neurodegenerative disorders, brain atrophy can occur, leading to a loss of neurons and their connections, decreased brain mass, and reductions in cognitive function and emotional regulation.


Psychedelic mushrooms stimulate signaling pathways that create new neurons, increase contact points between neurons, replace dead or damaged cells, and strengthen overall neural connectivity.

Additionally, serotonergic psychedelics have been found to reduce activity in the Default Mode Network (DMN), a brain region that maintains our sense of self and internal narratives. People with anxiety, depression, OCD, and ADHD often experience hyperactivity in the DMN. By reducing activity in the DMN, psychedelics have been shown to decrease hyper-rumination, compulsive drug-seeking behaviors, and increase focus on goal-oriented tasks.


In a 2008 study led by Roland R. Griffiths et al, 36 participants were contacted for a 14 month follow-up after being given a 30mg dose of psilocybin in a previous double-blind study. The follow-up study found that 21 of the 22 volunteers who had a complete mystical experience during the initial study continued to meet the criteria for a mystical experience 14 months later.


The study also found that participants reported increased well-being, life satisfaction, psychological openness, emotional connection to others, gratitude, and ability to live in the present. An increased connection to nature and aesthetic involvement with art were also reported as clinical evidence for enhanced sensory perception.

Overall, serotonergic psychedelics have the potential to stimulate neuronal growth and connectivity, reduce hyperactivity in the DMN, and improve emotional and cognitive function. These benefits have been observed in clinical trials and anecdotal reports, demonstrating the potential for psychedelics to improve mental health and well-being.


How to find your micro-dose:

When determining your microdosing dosage, it’s crucial to keep in mind that it should be sub-perceptual. This means that while enhancements to mood and cognition may be observed, you should feel generally sober throughout the day, with no impairment to your ability to perform normal everyday tasks.

A good starting point is 0.1 grams (100 mg) of psilocybin mushrooms a day for 3 consecutive days. Then taking a day or 2 days off, and then continuing with the microdose. If after a week you don’t feel effects, then try raising your dose to 150 mg or 200 mg following the same schedule.

You can continue the microdosing cycle for 4 to 8 weeks, up to 3 months. If you feel that a tolerance is building after some time, you can reset it by taking a 2 to 4 week rest period.

Eventually the idea is to microdose only for maintenance by developing habits of mind and emotional intelligence that allow you to balance your way of being and living.


When microdosing it's important to include practices like meditation, walking in nature, sun gazing, horizon gazing, affirmations, gratitude journaling, prayer and other practices that connect you to your higher self and spiritual nature.


I offer coaching/therapeutic sessions to help individuals in their process of microdosing, or if at some point they encounter some difficulties and need support and guidance during the microdosing process. You can contact me for more information about individual sessions (remote). trueisense@gmail.com




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